Author

Bret J. Pearson

Department of Molecular Genetics, University of TorontoORCID 0000-0002-3473-901XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:non-human primate· 1

Frequent Co-Authors

Alex Weiss· 1 shared Alexander V. KlimovichiD· 1 shared Alexander Y. LiniD· 1 shared Cassandra D'Amata· 1 shared Helen McNeilliD· 1 shared Madeline N HayesiD· 1 shared Maria BroouniD· 1 shared Mikhail BashkuroviD· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Alex Weiss

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3 papers

Recent·Most cited

Cancer BiologybioRxivOct 17, 2023

A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCA H1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

Alex Weiss, Cassandra D'Amata, Bret J Pearson, Madeline N Hayes

This study develops a zebrafish model of glioblastoma driven by specific oncogenic variants and shows inflammation inhibits tumor growth during initiation and relapse.

DOI 10.7554/elife.93077.3

zebrafishspatial transcriptomics

𝕏 PostBluesky

Developmental BiologybioRxivPreprintApr 9, 2019

Ancestral role of Fat-like cadherins in planar cell polarity

Maria Brooun, Alexander V. Klimovich, Mikhail Bashkurov…·Helen McNeill

This study identifies Fat-like and Dachsous cadherins in Hydra, showing their role in cell adhesion and planar polarity, suggesting ancient functions in bilaterian evolution.

2 citations

non-human primateexperimental assay

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Molecular BiologyPLoS GeneticsPeer-reviewedJul 7, 2017

Yorkie is required to restrict the injury responses in planarians

Alexander Y. Lin, Bret J. Pearson

This study shows that yorkie restricts hyper-activated injury responses in planarians, ensuring proper scaling of regenerative outcomes.

38 citations

plant (other)bulk RNA-seq

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