Sierra Smith

The paper identifies Lmx1b as a regulator of hyaluronan and Versican in zebrafish inner ear semicircular canal morphogenesis, showing how Versican controls hyaluronate density and hydration through its core and chondroitin side chains.

This study demonstrates that AAV-mediated MCOLN1 gene transfer improves motor function and reduces brain pathology in a mouse model of mucolipidosis IV.