Jeffrey P. MacKeigan

This study identifies ULK1-driven autophagy as a mechanism by which HPV+ HNC cells degrade MHC-I, promoting immune evasion and tumor growth.

This study quantifies autophagy responses in single U2OS cells to amino acid and glucose starvation, finding that amino acid starvation induces autophagy while glucose starvation does not.

This study uses molecular dynamics simulations to analyze how ULK-101 binds to ULK1/2 kinases, revealing structural features that explain its potency and selectivity.

The paper measures tissue distribution and tumor concentrations of hydroxychloroquine, quinacrine, and VATG-027 in mice using LC-MS/MS, showing varied tissue-specific accumulation.