Fang Chen

The paper develops a resource to improve cardiac modelling protocols using hPSC-CMs by analyzing decades of research data and providing tools for protocol benchmarking.

The paper shows that combinations of highly variable core genes can accurately predict sequence variants and antibiotic resistance in bacterial genomes.

The paper identifies rare damaging variants in outer DNAH genes in 22.5% of severe hypospadias patients, suggesting their role in the condition and potential for genetic counseling.

This paper investigates how sequencing depth affects low-frequency mutation detection, showing that increasing depth improves fidelity and sensitivity while reducing false positives.

The paper introduces a de novo scaffolding tool for synthetic long reads that improves assembly quality significantly, especially for assemblies from next-generation sequencing reads.

This study assesses how temporary storage conditions affect the transcriptome of peripheral blood leukocytes, identifying gene expression changes and stable reference genes.

This study creates the first single-cell chromatin accessibility atlas of the lancelet, revealing regulatory elements and developmental trajectories.

This study creates the first single cell atlas of T21 cerebral cortex, identifying dysregulated genes and developing a platform for data exploration.

This study creates the first single-cell brain atlas of domestic pigs, identifies cell types and their spatial distribution, and compares them with other species to reveal evolutionary and disease-related insights.

The paper shows that maternal H1 can compensate for the absence of BigH1 in Drosophila embryos, supporting normal development.

This study compares gene expression profiles of leukocytes from different isolation methods, finding that RBC lysis reduces globin mRNA and improves transcriptome quality.

The paper presents a single-cell transcriptomic analysis of nucleated cells in umbilical cord blood, identifying cell types, subpopulations, and transcriptional programs that may impact transplant outcomes.