Takefumi Negishi

The paper shows that Wnt proteins, receptors, and Dvl localize asymmetrically in C. elegans seam cells, linking Wnt gradients to cell polarity through positive feedback.

The paper investigates the distinct and cooperative roles of multiple Wnt ligands and receptors in regulating cell polarity orientation in C. elegans.

This paper develops a scAb-AID2 system for conditional protein degradation without requiring degron tags, demonstrating its effectiveness in human and C. elegans cells.

The paper shows LIN-5/NuMA regulates spindle orientation and tissue organization in C. elegans germ cells through polarized cortical localization.

The paper identifies a Nodal/Eph signalling relay that controls the transition from apical constriction to apico-basal shortening during ascidian endoderm invagination, without affecting cell fate specification.