Matthew T. Wolf

This study shows that tissue injury accelerates tumor growth and reduces response to immunotherapy in mice, but biomaterials that enhance wound healing can improve outcomes and ICB response.

This study investigates how the extracellular matrix affects AAV gene therapy by comparing diffusion and transduction efficiency across different AAV serotypes and ECM models.

This study evaluates how linear and branched PEGylation affects nanoparticle uptake and distribution in tumor and immune cells, showing branched PEG increases spleen accumulation and linear PEG enhances tumor uptake by immune cells.

This study evaluates how inflammatory adjuvants modulate the immune response and long-term remodeling of ECM scaffolds in a murine injury model.

This paper develops a 3D self-assembly system to engineer tumor stroma-like structures using decellularized ECM and cancer cells, showing effects on malignancy and metabolism.

This study investigates how tissue-specific ECM properties affect nanoparticle diffusion and cellular uptake, finding that PEGylation strategy impacts ECM penetration and uptake differently across tissues.

This study shows that ECM scaffolds enhance cancer vaccine efficacy by promoting cytotoxic immunity without compromising wound healing immune responses.