Justin M. Kollman

This paper shows human glutamine synthetase forms filaments stabilized by glutamine, reducing catalytic specificity for ammonia and linking product concentration to enzyme function.

This paper develops a covalent PFKL activator that disrupts cancer cell metabolism and delivers a cytotoxic payload, showing efficacy in vitro and in vivo.

The paper redesigns TALE proteins to assemble linear protein-DNA complexes on double-stranded DNA templates, enabling controlled length and application in antigen display.

This study identifies four antibody mechanisms that disrupt FimH-mediated bacterial adhesion by altering its conformation and glycan binding.

The paper designs and characterizes a random protein walker that diffuses along a designed protein track, finding that walkers with more feet move faster.

This study shows that Mycobacterium tuberculosis CTP synthase forms unique filaments that stabilize enzyme activity and resist inhibition, with mutations affecting filament formation under positive selection in clinical isolates.

This paper shows that an IMPDH2 variant linked to neurodevelopmental disorders disrupts purine biosynthesis and somitogenesis in Xenopus tropicalis by affecting filament assembly and GTP sensitivity.

This paper computationally designs multi-component protein filaments that assemble into ordered fibers, validated by cryoEM, and shows regulation via phosphorylation.

The paper identifies a family of bacterial actins forming a unique 3-stranded tubular structure via ATP binding, revealing new insights into bacterial cytoskeletal diversity.

This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.

This study determines the cryoEM structures of human PFK1 in R- and T-states, revealing eukaryotic allosteric regulation mechanisms and the role of the C-terminus in autoinhibition.

The paper shows that IMPDH2 is required for tail regeneration in Xenopus tropicalis and forms filaments in regenerating tissue under high GTP demand.

This paper shows phosphorylation at S477 regulates IMPDH1 filament assembly and activity, modulating GTP synthesis in retinal cells.

This paper computationally designs self-assembling protein rotary machines that sample internal rotational degrees of freedom based on energy landscapes.

The paper designs binary 2D protein co-assemblies that form ordered, biologically active materials with potential therapeutic applications.

The paper reports cryo-EM structures of human IMPDH2 showing filament assembly tunes allosteric regulation and reduces feedback inhibition.