Audrey G. O’Neill

This paper shows that an IMPDH2 variant linked to neurodevelopmental disorders disrupts purine biosynthesis and somitogenesis in Xenopus tropicalis by affecting filament assembly and GTP sensitivity.

The paper shows that IMPDH2 is required for tail regeneration in Xenopus tropicalis and forms filaments in regenerating tissue under high GTP demand.

This paper shows phosphorylation at S477 regulates IMPDH1 filament assembly and activity, modulating GTP synthesis in retinal cells.