David J. Beebe

This paper introduces a method to isolate and expand single bacteria from blood using droplet arrays, achieving faster detection than conventional blood culture.

This study shows lymphatic endothelial cells influence neutrophil migration, phagocytosis, and NETosis in a 3D infection model, with differential effects based on bacterial type.

ELRi isolates immune cells from small blood samples, revealing impaired T-cell migration to CCL21 in pediatric asthma.

This study identifies CXCL13-CXCR5 signaling as critical for CD8 T cell recruitment and immune organization in ccRCC, with potential as a biomarker and therapeutic target.

This paper develops a patient-specific microphysiological system to predict chemoradiation response in head and neck cancer by reconstructing tumor microenvironment complexity.

This paper develops a human microphysiological system to study neutrophil reverse migration mediated by macrophage-derived extracellular vesicles in sterile injury.

The paper discovers co-zorbs, motile multispecies biofilms formed by Flavobacterium johnsoniae that transport other bacteria, revealing a new type of bacterial movement and cooperation.

This study investigates the dual role of naive primary neutrophils in the tumor microenvironment, showing they both restrict tumor invasion and hinder NK cell penetration through ROS and NETs.

The paper uses a lung endothelial microphysiological system to study how sepsis plasma affects endothelial function, finding increased permeability and inflammatory markers.

This study identifies genes in Flavobacterium johnsoniae critical for surface colonization in both solitary and community settings using a model microbial community.

This study shows that ARPC1B in both neutrophils and endothelial cells regulates neutrophil motility, with endothelial ARPC1B being sufficient to drive neutrophil behavior.

This study uses a vascular microphysiological system to show that inflammatory mediators and activated PBMCs disrupt endothelial function by increasing permeability and reducing Ca2+ signaling.

The paper introduces a microfluidics-based nematode sensory assay to study gustation and shows that ivermectin inhibits gustatory ability in parasitic nematodes.

The paper introduces exclusion-based immunoprecipitation methods to identify RNA binding partners of CRD-BP in mammary epithelial cells, showing enrichment in mRNAs related to mitochondrial function and oxidative stress.