Irene M. Ong

The paper compares immune profiles and microbiomes of breast milk from mothers with different farm exposures to identify associations with immune development and atopic disease.

This study identifies a shark-derived VNAR that binds a hidden epitope on FAP, revealing structural insights for multiepitope targeting strategies.

This paper develops a novel syngeneic mouse model for HNSCC to study immune evasion and evaluates its response to immunotherapies.

ELRi isolates immune cells from small blood samples, revealing impaired T-cell migration to CCL21 in pediatric asthma.

This paper develops a patient-specific microphysiological system to predict chemoradiation response in head and neck cancer by reconstructing tumor microenvironment complexity.

This study compares the immune effects of alpha- and beta-particle emitting radiopharmaceuticals combined with immune checkpoint inhibitors in murine tumor models, finding distinct mechanisms of action based on radiation type.

The paper investigates how dietary restriction of specific essential amino acids affects metabolism and chromatin states in mice, finding distinct effects for methionine, leucine, and isoleucine.

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

MPAC infers pathway activities from multi-omic data to identify patient subgroups and clinically relevant proteins, demonstrating improved results over single-omic analyses in head and neck cancer.

This paper shows that low-dose radiopharmaceutical therapy enhances GD2 TRAC-CAR T cell efficacy in neuroblastoma by improving tumor regression and immune response.

The paper introduces HERON, an R package for identifying immunogenic epitopes from ultradense peptide binding arrays across multiple samples.

The paper identifies maternal milk and infant plasma antibody binding to human rhinovirus epitopes using high-density peptide arrays, revealing isotype-specific and virus-specific binding patterns.

MASH Native provides a unified software solution for processing native top-down proteomics data, offering database searching and analysis tools in a user-friendly interface.