Francesc X. Ruiz

This study identifies non-nucleoside inhibitors of EV-D68 3D polymerase through crystallographic fragment and high-throughput screening, revealing potential drug targets and lead compounds.

This study identifies multiple binding sites on the dengue virus polymerase through crystallographic fragment screening, providing insights for developing non-nucleoside antiflavivirals.

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

The paper analyzes 3D structural changes in SARS-CoV-2 proteins during the first six months of the pandemic, showing amino acid substitutions primarily affect surfaces and boundary layers.