Author

John R. Christin

Columbia University Irving Medical CenterORCID 0000-0002-0479-0308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Caroline J. Laplaca· 2 shared Hanina H. HibshooshiD· 2 shared Michael M. SheniD· 2 shared Andrew S. GreenbergiD· 1 shared Brent R. StockwelliD· 1 shared Fereshteh ZandkarimiiD· 1 shared Jingbo ZhouiD· 1 shared John P. ChuteiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersDevelopmental Biology

Caroline J. Laplaca

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2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintAug 6, 2025

Dual pathway regulation of castration response and ferroptosis in the prostate epithelium

Weiping Li, Jingbo Zhou, Zejian Wang…·Michael M. Shen

The paper shows that castration induces prostate epithelial regression via ferroptosis, mediated by two AR signaling pathways controlled by NKX3.1 and PTN.

DOI 10.1101/2025.08.06.668974

mousehuman

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Cancer BiologyGenome MedicinePeer-reviewedJan 17, 2025

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer

Luis Aparicio, Laura Crowley, John R. Christin…·Michael M. Shen

This study uses scRNA-seq data from mouse and human prostate tissues to show epithelial plasticity in regression, regeneration, and cancer, with findings on cell type origins and AR signaling heterogeneity.

15 citations

mousehuman

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