Somya Mehra

This study identifies MMV687794 as an inhibitor of Plasmodium falciparum RBC invasion by targeting PfSLIRP, a rhoptry protein involved in lipid metabolism and vacuole formation.

This study investigates the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum by combining chemoproteomic methods and genetic validation.

This study evaluates how genetic diversity in Plasmodium vivax antigens affects serological markers for malaria exposure and finds that using multiple antigens can improve detection accuracy.

This paper identifies systematic biases in malaria parasite relatedness estimation and proposes practical tools to address them.

This study evaluates the transmission-blocking effects of artesunate, chloroquine, and methylene blue on Plasmodium vivax gametocytes, finding that only artesunate and methylene blue significantly reduce oocyst and sporozoite development.

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

This study identifies MMV020291 as a compound that targets actin-1/profilin dynamics in Plasmodium falciparum, inhibiting red blood cell invasion and apicoplast segregation.

VIVID is a web tool that visualizes and interprets DNA variants in 3D on protein models to study genetic variation and its association with phenotypes.

This study demonstrates that Nanopore sequencing provides accurate SNV calls and detects structural variants in malaria parasite genomes, comparable to Illumina sequencing, and enables real-time, field-deployable whole genome sequencing.