Zahra Razook

This study identifies MMV687794 as an inhibitor of Plasmodium falciparum RBC invasion by targeting PfSLIRP, a rhoptry protein involved in lipid metabolism and vacuole formation.

This study investigates the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum by combining chemoproteomic methods and genetic validation.

This study identifies M-512 as an agonist of PfROM8 and PfCSC1, which are essential for Plasmodium falciparum growth, and shows that their dysregulation reduces parasite viability.

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

This study identifies MMV020291 as a compound that targets actin-1/profilin dynamics in Plasmodium falciparum, inhibiting red blood cell invasion and apicoplast segregation.

This study demonstrates that Nanopore sequencing provides accurate SNV calls and detects structural variants in malaria parasite genomes, comparable to Illumina sequencing, and enables real-time, field-deployable whole genome sequencing.