Alyssa E. Barry

This study shows that targeting PTRAMP-CSS inhibits Plasmodium falciparum across liver, blood, and mosquito stages, supporting its potential as a multistage vaccine target.

This study identifies EGF7 in PfRipr as a critical domain for inhibiting Plasmodium falciparum erythrocyte invasion and provides a basis for vaccine design.

This study identifies MMV687794 as an inhibitor of Plasmodium falciparum RBC invasion by targeting PfSLIRP, a rhoptry protein involved in lipid metabolism and vacuole formation.

This study investigates the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum by combining chemoproteomic methods and genetic validation.

This study evaluates how genetic diversity in Plasmodium vivax antigens affects serological markers for malaria exposure and finds that using multiple antigens can improve detection accuracy.

This study identifies M-512 as an agonist of PfROM8 and PfCSC1, which are essential for Plasmodium falciparum growth, and shows that their dysregulation reduces parasite viability.

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

The paper develops a molecular barcode and online tool to identify and map imported Plasmodium vivax infections using SNP analysis and machine learning.

This study identifies MMV020291 as a compound that targets actin-1/profilin dynamics in Plasmodium falciparum, inhibiting red blood cell invasion and apicoplast segregation.

VIVID is a web tool that visualizes and interprets DNA variants in 3D on protein models to study genetic variation and its association with phenotypes.

This study genotypes STRs in Plasmodium species using HipSTR and compares genetic diversity and population structure to SNP data, revealing higher resolution and unique signals.

This study demonstrates that Nanopore sequencing provides accurate SNV calls and detects structural variants in malaria parasite genomes, comparable to Illumina sequencing, and enables real-time, field-deployable whole genome sequencing.

The paper develops isoRelate, an IBD analysis method for haploid pathogens, identifies selection signals and population structure in Plasmodium falciparum data.