Sebastian A. Leidel

The paper identifies MIRINE, a small ORF-encoded polypeptide that promotes neuronal differentiation in vertebrate brain development by regulating the balance between proliferation and maturation.

The paper benchmarks cross-platform RNA modification quantification using LC-MS/MS and finds that harmonized workflows and SILIS normalization improve reproducibility across different instrument types.

This study identifies PCIF1 as a host factor that methylates the SARS-CoV-2 RNA cap, enhancing viral replication and reducing disease severity in mice.

This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.

This study shows that tRNA modifications affect codon pair decoding, leading to ribosome stalling and triggering quality control responses to prevent protein aggregation.

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.

This paper introduces a rapid ribosome profiling protocol for low-input samples, reducing RNA input to 0.1 pmol and enabling high-quality data from small samples.

This study shows that cycloheximide affects ribosome profiling data differently in yeast and human cells, suggesting that CHX may not be necessary for accurate human ribosome profiling.

This study shows estrogen receptor alpha (ER) regulates gene expression by coordinating transcription with translational offsetting, maintaining protein levels despite changes in mRNA abundance.

This paper develops a sensitive nLC-MS method using capillary porous graphitic carbon columns to quantify chemically modified ribonucleosides at attomol levels in complex samples.