NeurosciencebioRxivPreprint
Arrestin-3 promotes locomotor sensitization to psychostimulants via JNK signaling in nucleus accumbens
Mohamed Rafiuddin Ahmed, Jeffery L. Dunning, Chen Zheng…·Eugenia V. Gurevich
DOI 10.64898/2026.04.28.719936
Author
Vanderbilt UniversityORCID 0000-0002-0563-8295Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Mohamed Rafiuddin Ahmed, Jeffery L. Dunning, Chen Zheng…·Eugenia V. Gurevich
Chen Zheng, Mohamed Rafiuddin Ahmed, Richard C. Sando…·Eugenia V. Gurevich
This study identifies arrestin-3 as a scaffold for multiple MAP3Ks, with ZAK being the main mediator of JNK3 activation and chemotherapy-induced cell death in HEK293 cells.
Mohamed Rafiuddin Ahmed, Chen Zheng, Jeffery L. Dunning…·Eugenia V. Gurevich
The paper shows that restoring arrestin-3 in dopamine-depleted striatum rescues behavioral sensitization by reactivating JNK3 and c-Jun phosphorylation.