Richard C. Sando

The paper identifies FMIL-1 as a gene that directs synapse formation in a C. elegans nociceptive circuit by promoting connectivity between PVD neurons and PVC/AVA interneurons.

The paper develops methods to track excitatory and inhibitory synapses and finds their densities remain steady during maturation despite dynamic turnover.

This study identifies ADGRA1 as essential for hippocampal inhibitory synaptic function in PV and SST interneurons, showing its role in synaptic inputs and learning/memory.

This study identifies arrestin-3 as a scaffold for multiple MAP3Ks, with ZAK being the main mediator of JNK3 activation and chemotherapy-induced cell death in HEK293 cells.

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

This study shows that the C-terminal tail of LPHN2 modulates G protein and arrestin-3 signaling bias through alternative splicing and GRK interactions.

This study shows that Lphn1 is present in both excitatory and inhibitory synapses but is not essential for excitatory transmission, instead contributing to inhibitory synapse formation and function.

This study determines the structure of the CELSR1 extracellular region and shows how specific domains form a compact module to regulate cellular adhesion.

This study uses a novel approach to block long-term potentiation and finds that it selectively enhances salience coding in hippocampal neurons without affecting spatial memory.

The paper develops and validates a set of nanobodies for targeting proteins in brain neurons, providing a toolbox for visualization and modulation of subcellular sites.