João F. Passos

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

This study shows that aging-induced CD44 in hepatocytes activates the IL6/JAK/STAT3 pathway, leading to impaired T cell function in the liver.

SenoQuant is an AI software for analyzing and predicting senescence markers in tissues, offering spatial quantification across imaging modalities and supporting custom models.

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

This study shows that inactivating HIRA during embryonic development affects melanoblasts and leads to aging-related defects in melanocyte stem cells, but not in postnatal melanocytes.

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

This study shows that cellular senescence drives bone marrow adiposity in radiation- and aging-associated bone loss through miR-27a upregulation and senolytic treatment reduces BMAT.