Stefan Kempa

This study identifies IDHA-1 as a barrier to direct reprogramming of germ cells to neurons in C. elegans, showing metabolic and epigenetic mechanisms that maintain germ cell identity.

This paper develops a workflow integrating UHPLC-MS and MALDI-MSI to spatially map nucleosides in FFPE breast cancer tissues, revealing metabolic changes across tumor stages and validating findings in patient samples.

This study shows that spreading tau coordinates lipid homeostasis by promoting neuronal lipid efflux and enhancing resilience to lipid toxicity.

This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.

The paper uses GAM to study haplotype-specific 3D chromatin structures in mESCs, finding extensive allelic differences in chromatin architecture and gene expression mediated by Polycomb repression.

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

This study identifies mitochondrial adaptations in naked mole-rats that confer hypoxia resistance, linking social behavior to molecular evolution.

This paper identifies a multi-modal mechanism by which L-GA inhibits neuroblastoma cell growth through metabolic disruption, oxidative stress, and nucleotide biosynthesis inhibition.

This study identifies Rbm10 as a splicing factor that facilitates heterochromatin assembly through its interaction with the Clr6 HDAC complex in fission yeast.

The paper uses a kinetic model of central carbon metabolism to predict metabolic reprogramming in liver cancer and validates findings through experiments.

The paper identifies and characterizes conserved small ORFs in multiple animal species, finding novel micropeptides with evidence of translation and functional potential.