Hosni Cherif

This paper develops a standardized in vitro model for senolytic drug screening using human intervertebral disc cells and validates a metabolic activity assay as a scalable method to assess senolytic activity.

The paper identifies anti-inflammatory miRNAs in extracellular vesicles from human intervertebral disc cells and shows their synergistic effects in reducing inflammation and promoting regeneration.

This study shows that early senolytic treatment prevents low back pain in mice by reducing senescence markers and inflammation in spinal tissues.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.