Laura S. Stone

This study shows TRPC6 activation in human intervertebral disc cells causes calcium influx and activates MAPK and NF-κB pathways, leading to inflammation and catabolic responses.

This study investigates how prenatal maternal stress affects DNA methylation and gene expression in the prefrontal cortex, revealing sex-specific changes linked to increased pain sensitivity in adulthood.

This study shows that early senolytic treatment prevents low back pain in mice by reducing senescence markers and inflammation in spinal tissues.

This study shows chronic alcohol consumption delays recovery from pain-induced hypersensitivity in mice, with sex-specific effects on cold sensitivity and prolonged mechanical hypersensitivity.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.

The paper identifies a stress-induced subtype of nucleus pulposus cells in degenerating intervertebral discs that trigger discogenic low back pain.

This study examines epigenetic changes in the mouse prefrontal cortex over time following nerve injury, identifying persistent DNA methylation alterations associated with acute to chronic pain transition.