Andrew D. Dick

This study shows inflammatory arthritis disrupts the blood-retinal barrier and promotes T cell recruitment to the eye, increasing susceptibility to uveitis without causing overt ocular disease.

The paper identifies resident memory T cells in the human uveal tract, showing their presence in both healthy and inflamed states and their potential role in uveitis.

This study tracks pathogenic CD4 T cells in experimental uveitis and identifies shared features with other immune-mediated inflammatory conditions.

The paper identifies a novel population of IL-23 responsive T cells in the anterior uvea that drive uveitis and are present in humans.

This study shows age-related autophagy decline in RPE contributes to AMD, and topical trehalose improves autophagy and protects against light-induced retinal damage in mice.

The paper uses an autoencoder to derive retinal phenotypes from OCT images, identifies 118 genetic loci, and shows their relevance to retinal morphology and disease prediction.

This study shows that replenishing IRAK-M in retinal pigment epithelium reduces outer retinal degeneration in age-related macular degeneration.