Cell BiologybioRxivPreprint
ER cholesteryl ester phase separation underlies switch-like cholesterol sensing
Mehdi Zouiouich, Apoorva Bhapkar, Jennica Träger…·Abdou Rachid Thiam
The paper identifies cholesterol esterification as a mechanism that creates switch-like regulation of the INSIG/SCAP/SREBP2 pathway through ER membrane phase transitions.
DOI 10.64898/2026.08.01.740796