Mohyeddine Omrane

The paper identifies cholesterol esterification as a mechanism that creates switch-like regulation of the INSIG/SCAP/SREBP2 pathway through ER membrane phase transitions.

The paper shows that the CE/TG ratio determines lipid droplet size and phase behavior, influencing their function and disease relevance.

This study uses imaging and analysis to reveal the roles of the zona pellucida and perivitelline space in gamete fusion and polyspermy block in mice oocytes.

This paper identifies DDHD2 as a neutral lipid lipase and transacylase that remodels triglyceride acyl chains by transferring acyl groups between lipids.

The paper identifies steric repulsion as a mechanism regulating ER-to-LD protein movement, showing high-affinity proteins exclude lower-affinity ones during adipocyte differentiation.

This study shows that seipin regulates CAV1 trafficking and organelle interactions by controlling lipid metabolism and membrane order, impacting cellular homeostasis and metabolic disorders.

This paper investigates how perilipin membrane integration determines lipid droplet heterogeneity in differentiating adipocytes by showing that an unconventional integral membrane segment directs PLIN1 to the ER and influences LD-class specificity.

This study identifies two polybasic domains in septin 9 that mediate interaction with phosphoinositides and are critical for septin filament assembly and Golgi integrity.