John C. Newman

The paper introduces PickliPy, an open-source framework for converting assay designs into ADE picklists, enabling reproducible and scalable microplate-based experiments.

This study shows ketone body oxidation is essential for neuronal function and survival, particularly in neurodegenerative diseases like Alzheimer's.

This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.

This study shows that ketone bodies reduce brain energy metabolism disruption and prevent delirium-like cognitive deficits in aged mice during systemic inflammation.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

This study shows that a cyclic ketogenic diet reduces neuroinflammation in aging mice by modulating microglial responses to inflammatory stimuli.

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

This study shows that a short-term cyclic ketogenic diet improves memory and synaptic plasticity in aged mice by modulating the cAMP/PKA signaling pathway and cytoskeleton dynamics.

The paper shows that small-molecule ketone esters reduce epileptiform discharges and improve cognition in an Alzheimer's disease mouse model.