Huanzhu Jiang

This study uses tunable magnetorheological elastomer substrates to investigate mechano-genetic interactions in HCM by applying dynamic mechanical stress to hiPSC-derived cardiomyocytes with a MYBPC3 mutation.

This study shows that mechanical culture history affects iPSC-derived cardiac fibroblasts' phenotype and TGF-beta1 response, but later passages can alter these effects.

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.

This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.