Nathaniel Huebsch

This study uses tunable magnetorheological elastomer substrates to investigate mechano-genetic interactions in HCM by applying dynamic mechanical stress to hiPSC-derived cardiomyocytes with a MYBPC3 mutation.

This paper introduces a method to rapidly create customized, autoclavable cell culture accessories using polycarbonate thermoforming from 3D printed molds, demonstrating compatibility with human iPSC culture and differentiation.

This study shows that mechanical culture history affects iPSC-derived cardiac fibroblasts' phenotype and TGF-beta1 response, but later passages can alter these effects.

This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.

This paper develops a microfluidic platform to model sensory neuron-intervertebral disc crosstalk by combining biochemical and electric-field stimulation.

This study develops a xeno-free hydrogel platform to support hiPSC expansion and in situ differentiation into structurally mature cardiomyocytes.

The paper identifies stress granule coarsening as a critical factor in cardiac electrophysiological dysfunction under oxidative stress.

This study models human iron overload cardiomyopathy in vitro using engineered heart tissues, revealing differential effects on cardiomyocytes and fibroblasts and mechanisms of arrhythmogenesis and reduced contractility.

This study uses 3D-printed microdevices to show fibroblasts respond to directional stress through a hierarchical temporal cascade, influencing myofibroblast transition and tissue organization.

The paper shows that a common SCN5A variant, S1103Y, alters mexiletine's pharmacological response in induced pluripotent stem cell-derived cardiomyocytes, leading to proarrhythmic effects.

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.

This study shows that IGF-1 peptide mimetics functionalized on hydrogels enhance MSC survival and reduce inflammation in human intervertebral disc cells.

This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.