Author

Jeremiah C. Pfitzer

Auburn UniversityORCID 0000-0002-0785-8312Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Michael W. GramlichiD· 3 shared Miranda Nicole ReediD· 3 shared Morgan Hellums· 2 shared David Batista· 1 shared Delaney Gray· 1 shared Emma Redmon· 1 shared Erika Taipala· 1 shared Irfan QureshiiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersNeuroscience

Michael W. GramlichORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologyJournal of NeurochemistryPeer-reviewedAug 30, 2024

Troriluzole Rescues Glutamatergic Deficits, Amyloid and Tau Pathology, and Synaptic and Memory Impairments in 3xTg-AD Mice

Jeremiah C. Pfitzer, Priyanka D. Pinky, Savannah Perman…·Miranda N. Reed

This study shows troriluzole reduces glutamate release and cognitive deficits in 3xTg-AD mice by targeting presynaptic changes linked to AD pathology.

9 citations

mouseproteomics

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NeurosciencebioRxivPreprintJun 30, 2023

Mitochondria Exhibit Changes in Morphology/Function to Support Increased Glutamate Release in TauP301L Neurons Prior to Reduction in Presynaptic Vesicle Release

Rachel Cotter, Morgan Hellums, Delaney Gray…·Michael W. Gramlich

The paper shows that mitochondria in TauP301L neurons adjust their morphology and function to support increased glutamate release before presynaptic release mechanics change, suggesting a potential therapeutic target.

DOI 10.1101/2023.06.30.547132

mouseexperimental assay

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NeuroscienceFrontiers in Synaptic NeurosciencePeer-reviewedAug 3, 2022

rTg(TauP301L)4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release

Erika Taipala, Jeremiah C. Pfitzer, Morgan Hellums…·Michael W. Gramlich

This study shows that increased extracellular glutamate in tauP301L mice is due to higher VGLUT1 per synaptic vesicle, not increased exocytosis.

12 citations

mouseproteomics

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