Rozalyn M. Anderson

This study shows that caloric restriction in mice alters RNA processing and lipid composition across adulthood, linking these changes to metabolic reprogramming and lifespan extension.

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

The paper analyzes the canine gut microbiome across 900 dogs to identify factors influencing microbiome composition and develops a metagenomics-based aging clock.

This study develops a biophysical model of arteriolar vasodynamics in mice, revealing how neurogenic, astrocytic, and myogenic responses interact to regulate cerebral hemodynamics during rest and activation.

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

This study shows that long-term caloric restriction in rhesus monkeys leads to depot-specific changes in adipose tissue, with shared proteostasis pathways and species-conserved effects on subcutaneous fat.

This paper develops an in-silico model of the mouse cerebrovasculature to analyze how different vascular zones contribute to cerebral autoregulation and functional hyperemia across cortical depths.

This study investigates the role of PGC-1a in neuronal metabolism and brain aging, showing its cell-type specific regulation and involvement in metabolic adaptation and growth signaling.

This study shows that activating the adiponectin receptor with AdipoRon reduces tau pathology, metabolic dysfunction, and electrophysiological defects by targeting mitochondrial function and related pathways.

The paper introduces ImAge, an image-based biomarker of aging and rejuvenation using chromatin and epigenetic patterns, showing correlation with chronological age and response to interventions.