Josef P. Clark

This study shows that caloric restriction in mice alters RNA processing and lipid composition across adulthood, linking these changes to metabolic reprogramming and lifespan extension.

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

This study shows that long-term caloric restriction in rhesus monkeys leads to depot-specific changes in adipose tissue, with shared proteostasis pathways and species-conserved effects on subcutaneous fat.

This study investigates the role of PGC-1a in neuronal metabolism and brain aging, showing its cell-type specific regulation and involvement in metabolic adaptation and growth signaling.

This study shows that activating the adiponectin receptor with AdipoRon reduces tau pathology, metabolic dysfunction, and electrophysiological defects by targeting mitochondrial function and related pathways.