Julie Zikherman

The paper shows that virus-like particle-displayed antigens bypass BCR tolerance by triggering distinct signaling and transcriptional programs compared to soluble antigens.

This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.