Marcus J. Taylor

This paper introduces HUH-tag conjugation for site-specific protein functionalization of DNA origami, enabling efficient and cost-effective signaling-competent protein attachment.

The paper shows that LPS priming enhances TLR7-driven Myddosome assembly in macrophages, linking microbial exposure to immune adaptation and autoimmunity risk.

The paper constructs a synthetic signalosome using Death Domains and shows that its function depends on polymer stability and avidity, demonstrating these properties are tunable and not restricted to specific motifs.

This paper develops an optogenetic method to release single molecules in live cells, enabling controlled delivery of functional proteins and reconstitution of cellular functions at the single molecule level.

This study shows IRAK4 auto-phosphorylation activates IRAK oligomerization, controlling inflammatory signaling by promoting DD domain assembly and downstream IL-1 signaling.