Helge Ewers

This paper demonstrates that UR214-9 disrupts septin hetero-octamerization, leading to aberrant structures and impairing cancer cell functions.

The paper identifies a temperature- and lipid saturation-dependent transformation of ER membranes into rigid tubes under stress, driven by lipid demixing and protein segregation.

This study identifies septin-associated PIPKIγ splice variants as essential for midbody organization by generating PI(4,5)P2 required for centralspindlin recruitment and septin-microtubule association.

This study develops a multimodal imaging framework to analyze nanoscale reorganization of cytokinetic proteins during cell division, revealing a new substep and creating detailed molecular maps.

The paper investigates how synapsin-SV condensates organize presynaptic actin through LLPS, revealing their role in SV clustering and actin polymerization in lamprey and mammalian synapses.

This study shows that T cell protrusions enable rapid and localized initiation of CAR signaling by facilitating dynamic rearrangement of key signaling molecules.

The paper identifies AIFM1/AK2 interaction as a gatekeeper of mitochondrial ATP synthase, showing it is NADH-dependent and linked to metabolic state, with implications for mitochondrial diseases.

The paper identifies two functionally distinct ARF1 compartments involved in post-Golgi sorting and endocytic recycling, challenging the classical vesicle shuttling model.

The paper investigates how circadian period compensates for fluctuations in repressor protein turnover rates in single cells using fluorescently labeled proteins and mathematical modeling.

This paper develops an optogenetic method to release single molecules in live cells, enabling controlled delivery of functional proteins and reconstitution of cellular functions at the single molecule level.

This paper develops a semi-supervised deep learning pipeline for automated 3D segmentation of cryo-SXT tomograms, validated on mammalian cell ultrastructure and filopodia morphology.

The paper introduces a GUI-based software for automated neuronal morphology analysis, achieving accurate classification of neurites and reproducing manual annotations on a benchmark dataset.

The paper introduces a GUI-based software for efficient Bayesian clustering of single-molecule localization microscopy data, improving speed and usability.

The paper identifies MPP2 as a scaffold protein that links GABAA receptors to the postsynaptic density through super-resolution imaging and mass spectrometry.

This study uses interferometric scattering microscopy to track membrane protein motion in live neurons, revealing compartmentalized plasma membrane structures.