Dhiraj Kumar

This study identifies lysosomal acid lipase (LIPA) as a key enzyme regulating cholesterol metabolism during phagosomal maturation, linking lipid catabolism to antimicrobial defense.

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

This study identifies PfGBP-130 as the ligand for LFA-1 on Plasmodium falciparum-infected red blood cells, showing it mediates NK cell activation and parasite control.

The paper identifies a Q135K mutation in uvrA of Mycobacterium tuberculosis that confers survival advantage under oxidative stress and in macrophages, enhancing host adaptability.

This paper identifies a Mycobacterium tuberculosis secreted protein that disrupts host snRNP biogenesis, altering RNA splicing and contributing to pathogenesis.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.

This study analyzes PIH1D1 and p53 expression in pediatric brain tumors using TCGA data, identifying them as potential prognostic markers and therapeutic targets.

This study identifies a mitochondrial quality control mechanism that reverses phagosome maturation arrest caused by Mycobacterium tuberculosis through RAB7 recruitment and lysosomal targeting.