Dennis J. Stuehr

This study shows that sGC subunits act as Hsp90 co-chaperones to facilitate heme acquisition and functional maturation of apo-hemeproteins in mammalian cells.

This study shows that NO modulates airway smooth muscle function in asthma by altering G6PD effects on sGC function through redox regulation and heme-maturation.

This study shows that myoglobin leaks into the serum of anemic mice due to increased sGC activation and expression, which is linked to iron deficiency anemia.

The paper identifies FLVCR1b as the mitochondrial heme exporter that delivers heme to GAPDH and downstream hemeproteins in human cells.

The paper identifies inflammation regions in mouse asthma lungs that correlate with heme-free soluble guanylyl cyclase and HO1 expression, showing regional inflammation impacts lung function.

The paper visualizes mitochondrial heme flow through GAPDH to IDO1 in living cells and shows NO regulates heme reallocation between GAPDH and IDO1 based on NO levels.