ImmunologybioRxivPreprint
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
Jake Burton, Jesús A. Siller‐Farfán, Violaine André…·Omer Dushek
The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.
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