Author

Jitong Lou

University of North Carolina at Chapel HillORCID 0000-0002-1049-0416Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Cyrus VaziriiD· 2 shared Di WuiD· 2 shared Gaith N. DrobyiD· 2 shared Jay Ramanlal AnandiD· 2 shared Yang YangiD· 2 shared Abigail Shelton· 1 shared Akankshya JenaiD· 1 shared Andrew Benson SatterleeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Cyrus VaziriORCID

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2 papers

Recent·Most cited

Cancer BiologyNAR CancerPeer-reviewedJan 7, 2026

Differential roles of Rad18 in repressing carcinogen- and oncogene-driven mutagenesis in vivo

Jay Ramanlal Anand, Bethany L. Wagner, Jitong Lou…·Cyrus Vaziri

This study shows Rad18 suppresses 4NQO-induced oral carcinogenesis but not KrasG12D-driven lung tumors, highlighting context-specific tumor-suppressive roles.

1 citation

mouseDNA methylation

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Cancer BiologyNature CommunicationsPeer-reviewedMar 4, 2024

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

Xing Cheng, Jing An, Jitong Lou…·Yang Yang

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

46 citationstop 2%

humanDNA methylation

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