Brendan J. Houston

The paper constructs a comparative regulatory atlas of gonad development using mouse and human data, identifies a conserved enhancer critical for gonadal development, and prioritizes non-coding variants in DSD patients.

The paper shows how a resistance allele affects reproductive traits differently in male and female fruit flies depending on diet and insecticide exposure.

This study shows that Hsc70Cb is essential for spermatogenesis in Drosophila, with knockdown causing sterility and sperm defects, supporting its role in human male fertility.

This study identifies CCDC112 as essential for sperm mitochondrial sheath formation and epididymal maturation, impacting fertility and motility.

This study identifies AXDND1's role in balancing spermatogonial commitment and sperm tail formation in mice and humans, showing its necessity for fertility.

The paper identifies de novo mutations as a significant genetic cause of male infertility, finding several candidate genes and an enrichment of loss-of-function and missense mutations in intolerant genes.

This paper systematically reviews and validates monogenic causes of human male infertility, identifying 120 genes linked to 104 infertility phenotypes and assessing their clinical validity.