Ie‐Ming Shih

This study investigates the effect of statins on ovarian cancer survival, finding that atorvastatin improves survival and enhances immune activation in preclinical models.

The paper presents a 3D multi-omic framework to detect and characterize ovarian cancer precursors in fallopian tubes, identifying TP53 mutations in microscopic lesions.

This study shows that glutamine inhibition affects M1 macrophage polarization differently over time, enhancing pro-inflammatory activity while suppressing immunosuppressive macrophages.

The paper identifies four subtypes of ovarian precancerous lesions and links them to genetic and molecular features associated with cancer progression.

This study shows that inhibiting glutamine metabolism with JHU083 reduces tumor progression by altering macrophage polarization in immunocompetent mouse models.

The paper corrects gene models for PVRIG in scRNA-seq and bulk data, improving its detection and enabling accurate functional analysis.