Author
Alexander Yu. Nikitin
Cornell UniversityORCID 0000-0002-3729-7982Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 40 mutual co-author linksMutual co-authors in cluster
7 papers
Recent·Most cited
- BioengineeringAPL BioengineeringPeer-reviewed
Shape Factor Analysis as a Quantitative Framework for Assessing Spheroid and Organoid Morphology and Invasiveness
Brittany E. Schutrum, Jenny Deng, Ju Hee Kim…·Claudia Fischbach
This paper develops a shape factor analysis method to quantify spheroid and organoid morphology, showing it provides more reliable morphology assessments than standard shape descriptors.
DOI 10.1063/5.0333152 - Cancer BiologyCancer Heterogeneity and PlasticityPeer-reviewed
Keratin 5 marks cancer-propagating cells sustained by an osteopontin-producing niche in high-grade serous ovarian carcinoma
Mallikarjun Bidarimath, Coulter Q. Ralston, Nandini Bidarimath…·Alexander Yu. Nikitin
This study identifies KRT5-expressing cells as cancer-propagating cells in HGSC that depend on an OPN-producing niche for survival and chemoresistance.
2 citationstop 4% - Cancer BiologybioRxivPreprint
Comparative single-cell atlases reveal injury-driven tubal epithelial regeneration as a window for ovarian carcinoma initiation
Coulter Q. Ralston, Andrea Flesken‐Nikitin, Dah‐Jiun Fu…·Alexander Yu. Nikitin
The paper compares single-cell transcriptomes of mouse and human tubal epithelium to show injury-driven regeneration in humans may contribute to ovarian cancer initiation.
- Cancer BiologyThe Journal of PathologyPeer-reviewed
Dysregulation of cell state dynamics during early stages of serous endometrial carcinogenesis
Andrea Flesken‐Nikitin, Matalin G. Pirtz, Christopher S. Ashe…·Alexander Yu. Nikitin
This study identifies 44 genes, including novel markers like OAS2 and OASL, as potential early diagnostic and prognostic markers for serous endometrial carcinoma using a mouse model and multi-omics approaches.
- Cancer BiologybioRxivPreprint
Combinatorial organoid mutagenesis screen reveals gene constellations driving malignant transformation, pathology and chemosensitivity in high-grade serous ovarian carcinoma
Daryl J. Phuong, Coulter Q. Ralston, Tamer Ezzat…·John C. Schimenti
This study uses combinatorial CRISPR mutagenesis in organoids to identify gene combinations driving malignant transformation, pathology, and chemosensitivity in high-grade serous ovarian carcinoma.
- Cancer BiologyNature CommunicationsPeer-reviewed
Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma
Andrea Flesken‐Nikitin, Coulter Q. Ralston, Dah‐Jiun Fu…·Alexander Yu. Nikitin
The paper identifies pre-ciliated tubal epithelial cells as a cancer-prone state in high-grade serous ovarian carcinoma by analyzing mouse uterine tube cell states and lineage dynamics.
25 citationstop 4%