Laurent Désaubry

This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.

This study shows that reducing Flotillin-2 increases T-DM1 internalization and cytotoxicity in HER2-amplified cancers by enhancing HER2 ubiquitination and internalization.

This study develops capsaicin-derived ligands that modulate the AURKA/PHB2 interaction and mitophagy in cancer cells, with compound 13 showing promise as a specific inhibitor of AURKA-dependent mitophagy.

This study shows that PK2 signaling increases GDNF in astrocytes and that modulating PK2 receptors protects neurons in Parkinson's disease models.

The paper evaluates five PHB-targeting molecules in B cell lymphoma models, showing varied antiproliferative and cytotoxic effects across different cell lines.

This study shows that loss of Phb2 in Schwann cells disrupts myelination and dysregulates key transcription factors essential for peripheral nerve development.