Erica Ollmann Saphire

The paper determines cryo-EM structures of monoclonal antibodies bound to rabies virus glycoprotein, identifying new antigenic sites and their role in neutralization.

The paper identifies two broadly neutralizing antibodies against Ebolavirus glycoprotein and shows that one enhances the neutralization breadth and potency of other antibodies.

This study describes atypical Ebola virus disease in ferrets treated with a monoclonal antibody cocktail, showing delayed disease recrudescence with neurological involvement and brain inflammation.

This study identifies neutralizing epitopes on the measles virus fusion protein by analyzing monoclonal antibodies and their structural interactions with prefusion and postfusion conformations.

This study designs and tests a stabilized full-length measles fusion protein antigen that induces strong neutralizing antibodies and protects against viral challenge in a cotton rat model.

This study identifies protective human monoclonal antibodies against SARS-CoV-2 using a K18 hACE2 transgenic mouse model, showing that in vivo testing improves accuracy over in vitro assays.

The paper investigates how RNA folding influences host mRNA partitioning into Ebola virus condensates under different conditions and identifies implications for viral-host co-evolution.

This study identifies and characterizes human monoclonal antibodies against measles virus surface proteins, revealing their epitopes and mechanisms of neutralization.

This study determines the pre- and post-fusion structures of HERV-K Env using cryo-EM, revealing unique features that may inform therapeutic strategies.

This study presents a pre-fusion, open conformation of the SARS-CoV-2 S2 subunit and identifies antibodies that recognize it, providing insights into spike dynamics and potential vaccine targets.

This study identifies a new HCMV glycoprotein complex that enhances endothelial cell infection and presents it as a potential vaccine and antiviral target.

This study uses cryo-electron tomography to reveal the structure of the intracellular Ebola virus nucleocapsid, identifying a new outer layer of NP complexed with VP35 and conserved assembly interfaces.

This paper demonstrates how electron capture charge reduction (ECCR) combined with surface induced dissociation improves the characterization of protein complex topology and glycoprotein heterogeneity.

The paper identifies SARS-CoV-2 BA.1 epitopes recognized by mouse CD4+ T cells and generates corresponding tetramer reagents for studying immune responses.