Author

Leonard H. Rome

California Institute of TechnologyORCID 0000-0002-1236-2063Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Qing LouiD· 2 shared Randall McNallyiD· 2 shared Z. Hong ZhouiD· 2 shared Abby Zhaoqing Wang· 1 shared Ayrea E. HurleyiD· 1 shared Buhle MoyoiD· 1 shared David T. CurieliD· 1 shared Evan R. WilliamsiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Qing LouORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 29, 2026

Vault Packaging Dynamics: Cargo Loading Stabilizes MVP Conformation for High-Payload Cytokine Delivery in Cancer Therapy

Leonard H. Rome, Qing Lou, Zachary M. Miller…·Evan R. Williams

This study characterizes the structural dynamics of recombinant vaults, showing that cargo loading stabilizes their conformation for high-payload cytokine delivery in cancer therapy.

DOI 10.64898/2026.10.27.762310

yeastelectronic health records

𝕏 PostBluesky

BioengineeringACS Synthetic BiologyPeer-reviewedAug 13, 2026

Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy's neutralizing antibody problem

Logan Thrasher Collins, Wandy L. Beatty, Buhle Moyo…·David T. Curiel

This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.

3 citations

humanexperimental assay

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