Qing Lou

This study characterizes the structural dynamics of recombinant vaults, showing that cargo loading stabilizes their conformation for high-payload cytokine delivery in cancer therapy.

This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.

This study identifies IMC1 as a critical component of the Toxoplasma gondii inner membrane complex, showing its role in morphology, replication, and infectivity through expression timing, knockout, and interaction analyses.

This paper determines the structural basis of motility in Shewanella oneidensis using cryoET and cryoEM, revealing molecular mechanisms of curvature generation and engineering principles for biomimetic systems.