Author

Jeffrey D. Mewburn

Queen's UniversityORCID 0000-0002-1365-4228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Stephen L. ArcheriD· 3 shared Ashley Y MartiniD· 2 shared Asish DasguptaiD· 2 shared Kimberly J. Dunham‐SnaryiD· 2 shared Kuang‐Hueih Chen· 2 shared M. Martin VandenBroekiD· 2 shared Mark L. OrmistoniD· 2 shared Rachel E. T. BentleyiD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMolecular Biology

Stephen L. ArcherORCID

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Author profile →

4 papers

Recent·Most cited

Molecular BiologyArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewedAug 7, 2025

Circular RNA profiling identifies circ5078 as a BMPR2-derived regulator of endothelial proliferation and stress responses

M. Martin VandenBroek, M.C. Sharp, Patrick Thompson…·Mark L. Ormiston

The paper identifies circ5078 as a BMPR2-derived circular RNA that regulates endothelial proliferation and stress responses in PAH, with opposing effects to linear BMPR2 mRNA.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 8, 2025

The Core Subunit NDUFS2 in Mitochondrial Electron Transport Chain Complex I is Critical to Oxygen Responsiveness of Human Ductus Arteriosus Smooth Muscle Cells

Rachel E. T. Bentley, Kimberly J. Dunham‐Snary, Ashley Y Martin…·Stephen L. Archer

This paper shows that NDUFS2 in mitochondrial Complex I is critical for oxygen responsiveness in human DASMCs, affecting calcium, cell shortening, and mROS without altering respiration.

DOI 10.1101/2025.07.08.663799

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyCancer ResearchPeer-reviewedApr 29, 2025

Fes-deficient macrophages enhance CD8+ T cell priming and tumour control through increased proinflammatory cytokine production and localization

Brian J. Laight, Danielle Harper, Natasha Dmytryk…·Peter A. Greer

3 citations

mousebulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologyHypertensionPeer-reviewedAug 20, 2024

Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension

Danchen Wu, Ross D. Jansen‐van Vuuren, Asish Dasgupta…·Stephen L. Archer

This study evaluates Drpitor1a, a Drp1 inhibitor, showing efficacy in reducing PAH in female rats and human PASMCs without toxicity.

21 citationstop 3%

humanrat

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