Micah A. Chrenek

The paper compares transcriptomic differences between high and low flow regions in mouse and human trabecular meshwork to understand intraocular pressure regulation.

This study shows that dietary serine reduces ROS accumulation and improves retinal function in AMD by restoring mitochondrial function and GSH levels through PHGDH regulation.

This study shows that microtubule stability affects Schlemm's canal cell mechanics and outflow facility in glaucoma by altering contractility, stiffness, and pore formation.

The paper uses high-resolution 3D imaging to analyze RPE cell structure, revealing that apparent multinucleation often results from displaced nuclei and lateral membranes, not true fusion.

This study identifies HIFN, a novel TrkB activator, which improves visual function and retinal neuron survival in a mouse model of ocular trauma.

This study shows that PEDF deficiency in mice increases light-induced retinal damage, with worsened visual function, retinal thinning, and Galectin-3 expression.

This study shows that oral Nicotinamide Riboside (NR) treatment protects retinal ganglion cells (RGCs) and optic nerve axons in DBA/2J mice, likely through increased retinal NAD+ levels, and also prevents iris depigmentation and delayed IOP elevation.

This study evaluates age-related changes in RPE structure and function in C57BL/6J mice, finding increased alpha-catenin expression and immune cell recruitment in aged mice.

This study shows that the circadian clock in the RPE controls the daily phagocytic peak of photoreceptor outer segments, but its disruption does not cause age-related degeneration in the retina or RPE.

This study shows that systemic NR treatment protects against retinal degeneration in three mouse models by preserving retinal function and structure and increasing NAD+ levels.