Cancer BiologyJournal for ImmunoTherapy of CancerPeer-reviewed
Adipose contributes to CXCL5 regulated immune evasion in pancreatic cancer
R. McKinnon Walsh, Joseph Ambrose, Jarrid L. Jack…·Michael Nathan VanSaun
This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.
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