Author

Fardin Ghobakhlou

Université de MontréalORCID 0000-0002-1391-2012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Catherine Paradis‐Bleau· 2 shared Alan G. HinnebuschiD· 1 shared Felipe CavaiD· 1 shared Hongen ZhangiD· 1 shared Imène Kouidmi· 1 shared Larbi Mokhtari· 1 shared Laura ÁlvareziD· 1 shared Swati GaikwadiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

Catherine Paradis‐Bleau

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 9, 2025

High-throughput LacZ/CPRG screen identifies novel potential antibiotics targeting Gram-negative bacterial envelopes to combat resistance

Fardin Ghobakhlou, Larbi Mokhtari, Tom A. Pfeifer, Catherine Paradis‐Bleau

This study identifies 57 compounds, including three non-antibiotics, that disrupt Gram-negative bacterial envelopes using a LacZ/CPRG reporter assay, with alexidine showing the strongest activity.

2 citations

E. colimouse

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 10, 2024

Phenotypic and Transcriptomic Characterization of ElyC-Defective Escherichia coli Cells Reveal the Importance of ElyC in Cell Envelope Biology at Optimal and Sub-Optimal Temperatures

Fardin Ghobakhlou, Imène Kouidmi, Laura Álvarez…·Catherine Paradis‐Bleau

This study shows ElyC is essential for cell envelope integrity and PG biosynthesis at 21°C but has a moderate role at 37°C, affecting morphology, antibiotic resistance, and stress response pathways.

DOI 10.1101/2024.04.10.588480

E. colibulk RNA-seq

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GeneticsbioRxivPreprintOct 6, 2023

Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo

Swati Gaikwad, Fardin Ghobakhlou, Hongen Zhang, Alan G. Hinnebusch

This study investigates the role of eIF2A in yeast translation, finding minimal impact on translational efficiency and uORF-mediated control in vivo.

DOI 10.1101/2023.10.06.561292

yeastproteomics

𝕏 PostBluesky