Felipe Cava

This study identifies LptZ as a critical protein linking surface lipoprotein export to outer membrane vesicle biogenesis in Bacteroides, revealing a novel pathway and expanding the role of the Lpt machinery.

This study uses chemical genomics to identify gene-phenotype relationships in Vibrio cholerae by screening 104 stress conditions across 3,026 single-gene mutants, revealing 1,518 significant growth phenotypes including 88 unannotated genes.

This study identifies PBP2a as an RNA-binding protein in MRSA, showing it interacts with hundreds of transcripts and its RNA-binding activity is crucial for oxacillin resistance.

This study identifies LdtB as essential for Mycobacterium tuberculosis acid resistance by linking peptidoglycan cross-linking to intrabacterial pH homeostasis and antibiotic susceptibility.

This paper shows that disrupting undecaprenyl phosphate recycling via DedA4 deletion reduces AmpC beta-lactamase production and beta-lactam resistance in P. aeruginosa.

This study shows Streptomyces venezuelae uses both polar and dispersed growth mechanisms during rapid growth, with MreB playing a key role in cell wall integrity and structure.

This study identifies a novel mechanism in bacterial sporulation where programmed peptidoglycan degradation by lytic transglycosylases LtgA and LtgB controls morphological changes, preventing non-resistant pseudospore formation.

This study identifies how the ChvG-ChvI pathway in Agrobacterium tumefaciens promotes survival under cell wall stress through exopolysaccharide production, beta-lactamase activity, and outer membrane remodeling.

This paper identifies the roles of FimV, FlhF, and FleN in regulating the position, timing, and number of flagella assembly in Pseudomonas putida.

This study shows that spherical mreB deletion mutants of Pseudomonas fluorescens SBW25 can regain fitness through mutations in Pbp1A, restoring cell size homeostasis and supporting a hypothesis about balanced transpeptidase and glycosyltransferase functions.

This study identifies the essential role of LD-transpeptidation in Agrobacterium tumefaciens cell wall integrity and growth by analyzing LDTs and their genetic interactions.

This study identifies SpoVK as a chaperone that activates MurG during spore surface assembly in Bacillus subtilis, highlighting the need for specialized chaperones in specific nanoenvironments.

The paper reports the structure and function of PrgK, a component of the T4SS in pCF10, revealing its muramidase activity and self-regulating domains.

This study shows ElyC is essential for cell envelope integrity and PG biosynthesis at 21°C but has a moderate role at 37°C, affecting morphology, antibiotic resistance, and stress response pathways.

This study investigates the role of VirR in Mycobacterium tuberculosis vesicle production and links it to cell wall remodeling, suggesting potential therapeutic targets.

This paper identifies and characterizes a novel LD-transpeptidase in Gluconobacter oxydans that forms 1,3-type crosslinks, revealing structural and functional differences from known transpeptidases.

This study shows that Staphylococcus aureus counters acetate-mediated inhibition of peptidoglycan cross-linking by maintaining high intracellular D-Ala levels through alanine racemase and limiting D-Ala flux via D-alanine aminotransferase.